It was then the three found Sunnyside Daycare, prompting Lotso to take control over the other toys at the Daycare and rule the daycare with Big Baby as his primary enforcer. Feeling betrayed, Lotso forced Big Baby and Chuckles to leave with him.įor some time, the three toys travelled, hitching a ride on a Pizza Planet Delivery Truck until the truck hit a bump, causing the three toys to fall onto the street. Desperate to reunite with Daisy, Lotso, along with Chuckles and Big Baby, travelled to Daisy's house, only to find out that Daisy had gotten a new Lotso teddy bear. After some playtime, Daisy fell asleep, and her parents drove off with her, accidentally forgetting the three toys. One day, Daisy took Lotso, along with two other toys, Chuckles and Big Baby, with her parents for a picnic. Lotso formed a special bond with Daisy, becoming her most favorite toy. Lotso was a Christmas present for a girl named Daisy. He appears as the main antagonist of Toy Story 3 and was voiced by the late Ned Beatty. Lots-o'-Huggin' Bear, known more commonly as simply Lotso, is an extra soft evil anthropomorphic strawberry scented teddy bear, the former ruler of Sunnyside Daycare, and the arch-nemesis of Woody. His cane (which is actually a wooden toy mallet) Himself being evil, abusing the other toys, power, slaving innocent toys, bullying, abusing and insulting Woody, telling lies, Daisy (formerly), torturing toy owners (especially Woody and his friends), crueltyĭump, disobedience, trash, being abandoned, betrayal, being replaced, being told he was wrong Ken (formerly), Big Baby (formerly), Stretch (formerly), Twitch (formerly), Chunk (formerly), Sparks (formerly), Bookworm (formerly), Monkey (formerly) Buzz Lightyear (Demo Mode) Potato Head, Jessie, Slinky Dog, Ken, Stretch, Twitch, Chunk, Big Baby, Sparks, Bookworm, Chatter Telephone, The Monkey, Barbie, Chuckles, Daisy Woody (archenemy), Buzz Lightyear, Hamm, Rex, Mr. Potato Head (briefly), Jessie (briefly), Slinky Dog (briefly), Barbie (briefly), Prove to all the toys that the children do not want them anymore.ĭaisy's House (formerly), Sunnyside Daycare (formerly), Tri-County LandfillĬhuckles (formerly), Ken (formerly), Big Baby (formerly), Stretch (formerly), Twitch (formerly), Chunk (formerly), Sparks (formerly), Bookworm (formerly), Monkey (formerly), his owner Daisy (formerly), Woody (briefly), Buzz Lightyear (briefly and on Demo Mode), Hamm (briefly), Rex (briefly), Mr. Rule over Sunnyside Daycare as a prison forever at all costs. Supreme "Ruler" of Sunnyside Daycare (formerly) Obese extra-soft teddy bear, with a pink and white plush body, a dark-pink nose
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Stephen Colletti as Chase Adams (8 episodes).Gregory Harrison as Paul Norris (8 episodes).Mitch Ryan as Alexander Coin (10 episodes).Danneel Harris as Rachel Gatina (10 episodes).India de Beaufort as Miranda Stone (12 episodes).Daphne Zuniga as Victoria Davis (12 episodes).Jana Kramer as Alex Dupré (20 episodes).Paul Johansson as Dan Scott (13 episodes).Lisa Goldstein as Millicent Huxtable (19 episodes).Antwon Tanner as Skills Taylor (11 episodes).Lee Norris as Mouth McFadden (18 episodes).Jackson Brundage as Jamie Scott (16 episodes).Shantel VanSanten as Quinn James (22 episodes).Robert Buckley as Clay Evans (22 episodes). Austin Nichols as Julian Baker (22 episodes).Sophia Bush as Brooke Davis (22 episodes).Bethany Joy Galeotti as Haley James Scott (22 episodes).James Lafferty as Nathan Scott (22 episodes).While old romances, Mia and Chase seem to struggle, new ones form, Miranda and Grubbs, give in and begin a relationship, while Victoria and Alexander decide to take their professional relationship to the next level. Newcomers Clay and Quinn settle in Tree Hill and soon fall for one another, only to have their own dramas from ex husbands, dead spouses, and a troubling psycho. Mouth and Millicent's relationship is also threatened when Millie decided to become a model, but suffers serious self-image and develops a mini drug problem. Rachel and Dan return to Tree Hill and Brooke hires a new model (Alex) for "Clothes Over Bros" that in turn threatens her relationship with Julian. A scandal threatens Nathan's career in the NBA Haley goes back on the road, but suffers a family tragedy that causes her to battle a period of depression. It's been a year since Lucas and Peyton left Tree Hill. ^ "Paris: Renamed ARIA, Vasogenic Edema Common to Anti-Amyloid Therapy | ALZFORUM"."Anti-Aβ Autoantibodies in Amyloid Related Imaging Abnormalities (ARIA): Candidate Biomarker for Immunotherapy in Alzheimer's Disease and Cerebral Amyloid Angiopathy". "Amyloid Related Imaging Abnormalities (ARIA) in Amyloid Modifying Therapeutic Trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup". One or more separate sites of involvement may be noted.ĪRIA-H superficial siderosis ( Hemosiderin) ARIA MRI Classification Criteria ARIA MRI Classification Criteria ARIA TypeįLAIR hyperintensity confined to sulcus and/or cortex/subcortical white matter in one location 10 cm, often with significant subcortical white matter and/or sulcal involvement. The prevalence of mH in healthy elderly people is approximately 6%, but this value increases to between 50% and 80% in elderly people with cerebrovascular disease. Some studies define mH as being less than or equal to 10mm, while others define the cut-off as ≤ 5mm. mH are usually seen as small, round and low intensity lesions and are small haemosiderin deposits. ARIA-H ĪRIA-H refers to cerebral microhaemorrhages (mH), small haemorrhages on the brain, often accompanied by hemosiderosis. Symptoms may include headache, changes in mental state, confusion, vomiting, nausea, tremor and gait disturbances. The effect of ARIA-E depends on the severity and location of the edema. A further 7 patients developed ARIA-E during an open-label extension of the trial. In a double-blind trial of the humanised monoclonal antibody solanezumab (n = 2042), sixteen patients (11 taking the drug, 5 taking a placebo), or 0.78% developed ARIA-E. ARIA-E ĪRIA-E refers to cerebral edema, involving the breakdown of the tight endothelial junctions of the blood-brain barrier and subsequent accumulation of fluid. The phenomenon was first seen in trials of bapineuzumab. There are two types of ARIA: ARIA-E and ARIA-H. ARIA is associated with amyloid-modifying therapies, particularly human monoclonal antibodies such as aducanumab. Two MRI scans demonstrating the difference between ARIA-E (left) and ARIA-H in the parietal region (right)Īmyloid-related imaging abnormalities ( ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. Medical condition Amyloid-related imaging abnormalities Gladstein, “Groups in Context: A Model of Tas Group Effectiveness,” Administrative Science Quarterly 29 (December 1984): 499–517 D.G. Research shows that X-teams often outperform their traditional counterparts.ġ. X-teams manage across boundaries - lobbying for resources, connecting to new change initiatives, seeking up-to-date information and linking to other groups inside and outside the company. Instead, teams must be able to adapt to the new competitive landscape, as X-teams do. In fact, too much focus inside the team can be fatal. (See “About the Research.”) Teams that succeed today don’t merely work well around a conference table or create team spirit. Our studies all support the notion that the rules handed down by best-selling books on high-performing teams need to be revised. In other cases, forward-looking companies have established specific organizational incentives to support X-teams and their high performance levels. In some cases, they appear spontaneously. The current environment - with its flatter organizational structures, interdependence of tasks and teams, constantly revised information and increasing complexity - requires a networked approach. Product-development teams have been more innovative - and have been more often on time and on budget. Drug-development teams have been more adept at getting external technology into their companies. Sales teams have brought in more revenue. One such team in the oil business has done an exceptional job of disseminating an innovative method of oil exploration throughout the organization. These new, externally oriented, adaptive teams, which we call X-teams, are seeing positive results across a wide variety of functions and industries. Their entrepreneurial focus helps them respond more nimbly than traditional teams to the rapidly changing characteristics of work, technology and customer demands. Successful teams emphasize outreach to stakeholders both inside and outside their companies. Why do bad things happen to good teams? Our research suggests that they are too inwardly focused and lacking in flexibility. Another group worked well as a team but didn’t gather important competitive information its product was obsolete before launch. But because team members failed to get buy-in from division managers, they saw their project starve for lack of resources. We know one such team that had a highly promising product. Often teams that seem to be doing everything right - establishing clear roles and responsibilities, building trust among members, defining goals - nevertheless see their projects fail or get axed. In 2018, Scopus started embedding partial information about the open access status of works, using Unpaywall data. Scopus IDs for individual authors can be integrated with the non-proprietary digital identifier ORCID. It provides citation data for all 25,000+ active titles such as journals, conference proceedings and books in Scopus and provides an alternative to the impact factor, a journal-level indicator which may correlate negatively with reliability. In 2016, a gratis website, Scopus CiteScore, was introduced. It has alerting features that allow registered users to track changes to a profile and a facility to calculate authors' h-index. Scopus also offers author profiles which cover affiliations, number of publications and their bibliographic data, references, and details on the number of citations each published document has received. However, Scopus and WOS complement each other as neither resource is all-inclusive." The multidisciplinary aspect allows the researcher to easily search outside of his discipline" and "One advantage of WOS over Scopus is the depth of coverage, with the full WOS database going back to 1945 and Scopus going back to 1966. The ability to search both forward and backward from a particular citation would be very helpful to the researcher. Overview Ĭomparing ease of use and coverage of Scopus and the Web of Science (WOS), a 2006 study concluded that "Scopus is easy to navigate, even for the novice user. Searches in Scopus also incorporate searches of patent database Lexis-Nexis, albeit with a limited functionality. All journals covered in the Scopus database are reviewed for sufficiently high quality each year according to four types of numerical quality measure for each title those are h-Index, CiteScore, SJR ( SCImago Journal Rank) and SNIP ( Source Normalized Impact per Paper). It covers three types of sources: book series, journals, and trade journals. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences. Scopus is Elsevier's abstract and citation database launched in 2004. Life sciences social sciences physical sciences health sciences For other uses, see Scopus (disambiguation). “Blast, we’re not done yet!” he yells in alarm, and the three Lords accompanying him whirl to see three men walk through the gate. His eyes are drawn towards the Dragon’s Gate, which suddenly opens. I’m amazed you’re not even singed!” Marc says, absently beating out an ember that caught the hem of his cloak. “When I got caught? You took the brunt of that. “Ha! I thought we were done for when he got caught in a blast from that thing,” Hector barks. “Same way we did,” Lyn says, “Strength, luck, and good tactics.” She turns to smile at Marc, the group’s tactician, with the last word. “Us surviving? How did our ancestors win? And against hordes of the things!” Eliwood says. “Gods, how did we survive that?” he says, putting his hand to the still-warm corpse of the Fire Dragon that had made its way through the Dragon’s Gate at Nergal’s behest. He looks around, and sees Lyn and Eliwood stowing their own weapons, catching their breath after the long fight. Hector slings Armads over his shoulder, breathing heavily.
The 2022 Toyota C-HR has four different trims available, with the most affordable model to insure being the LE model at an average cost of $1,192 per year. Out of four Honda HR-V trim levels, the lowest-cost 2022 trim level to insure is the LX trim at an average cost of $1,320 per year, or $110 per month. 2022 Toyota C-HR Insurance Cost Vehicle Make/Model The table shown below compares and ranks the 12-month and monthly car insurance cost for 2022 Honda HR-V and Toyota C-HR models, showing average premium cost for each trim level.Ģ022 Honda HR-V vs. To illustrate this, on a 2022 Honda HR-V, car insurance rates range from the lowest full-coverage rate of $1,320 per year for the LX model up to the highest rate of $1,414 for the EX-L model.įor the 2022 Toyota C-HR, rates can range from $1,192 per year on the LE model up to $1,332 on the most expensive to insure Limited model. Within each model, however, car insurance cost varies noticeably depending on the trim level being insured. Insurance on a Honda HR-V costs an average of $1,370 per year, whereas insurance for a Toyota C-HR averages $1,254 per year. Is a Honda HR-V or Toyota C-HR cheaper to insure?įor 2022 Honda HR-V and Toyota C-HR models, the model with cheaper average insurance rates is the Toyota C-HR. of $1,567 per year, the Honda HR-V costs $197 less per year, while the Toyota C-HR averages $313 less per year. When compared to the average cost to insure a car in the U.S. For a 2022 Honda HR-V, average full-coverage car insurance rates range from $1,320 to $1,414 per year, while auto insurance for a 2022 Toyota C-HR ranges from $1,192 to $1,332.A 2022 Toyota C-HR is cheaper to insure than a 2022 Honda HR-V by an average of $116 per year, $1,370 compared to $1,254. Support for the pre-Django 3.1 () signatures.(encoded with the SHA-1 algorithm) is removed. Support for the pre-Django 3.1 signatures.Support for the pre-Django 3.1 encoding format of sessions is removed.Use the SHA-1 hashing algorithm) is removed. Support for the pre-Django 3.1 password reset tokens in the admin site (that.Support for the pre-Django 3.1 encoding format of cookies values used byĭ.cookie.CookieStorage is removed.The HttpRequest.is_ajax() method is removed.The django-admin.py entry point is removed.The django.db.models.query_utils.InvalidQuery exception class is removed.The isnull lookup no longer allows using non-boolean values as the.The PASSWORD_RESET_TIMEOUT_DAYS setting is removed.See Features deprecated in 3.1 for details on these changes, including how alias=None is required in the signature ofĭjango.db._group_by_cols() subclasses._language() doesn’t set the user language in.Ugettext_noop(), ungettext(), and ungettext_lazy() are removed. (), urlquote_plus(), urlunquote(), and.See Features deprecated in 3.0 for details on these changes, including how These features have reached the end of their deprecation cycle and are removed It is expected these methods return a SafeString. The ability to return a str from ErrorList and ErrorDict isĭeprecated.Since form rendering now uses the template engine, the undocumentedīaseForm._html_output() helper method is deprecated. The .GeoModelAdmin and OSMGeoAdmin classes.If you need the previous behavior, explicitly setĭefault to Value(), Value(''), or Value(''). None when there are no rows instead of, , and '' The extra_tests argument for DiscoverRunner.build_suite() andĭn_tests() is deprecated.Request will change from 'http' to 'https' in Django 5.0. The default sitemap protocol for sitemaps built outside the context of a.The undocumented _safe module is deprecated.The undocumented module is deprecated.SERIALIZE test setting is deprecated as it can be inferred from the.The minimum supported version of asgiref is increased from 3.3.2 to.Localization section above for more details.ĭ is changed to alias The default value of the USE_L10N setting is changed to True.USE_L10N setting and always returns localized output. The floatformat template filter no longer depends on the.Need the previous behavior, override the widget template with the appropriate template from Support for cx_Oracle tags so they are announced more concisely by screen readers.The new default argument for built-in aggregatesĪllows specifying a value to be returned when the queryset (or grouping).Lookup expressions may now be used in QuerySetĪnnotations, aggregations, and directly in filters.The skip_locked argument of lect_for_update() is now.Specifying a value to return when the function is used over an empty result The new Expression.empty_result_set_value attribute allows.QuerySet.bulk_update() now returns the number of objects updated.DurationField now supports multiplying and.QuerySet.bulk_create() now sets the primary key on objects when using.Specifying the number of decimal places after rounding. Query in the simplest and fastest way possible. Whether the queryset contains the given object. Transitional setting is recommended if you need a gradual update path. Using pytz_deprecation_shim and the USE_DEPRECATED_PYTZ Migration guide showing how to move to the new zoneinfo APIs. Provides shims to help you safely remove pytz, and has a detailed In addition, a pytz_deprecation_shim package, created by the zoneinfoĪuthor, can be used to assist with the migration from pytz. Setting allows continued use of pytz during the 4.x release cycle. To give time for such an audit, the transitional USE_DEPRECATED_PYTZ However, if you are working with non-UTC time zones, and using the pytz normalize() and localize() APIs, possibly with the TIME_ZONE setting, you will need to audit your code, since pytzĪnd zoneinfo are not entirely equivalent. Selection of theĬurrent timezone, conversion of datetime instances to the current timezone inįorms and templates, as well as operations on aware datetimes in UTC are The move to zoneinfo should be largely transparent. Theīackports.zoneinfo package is automatically installed alongside Django if Zoneinfo is part of the Python standard library from Python 3.9. Support for pytz is nowĭeprecated and will be removed in Django 5.0. DjangoĤ.0 makes zoneinfo the default implementation. Django 3.2 allowed the use of non- pytz time zones. This is the next step in the migration from using pytz to using The Python standard library’s zoneinfo is now the default timezone Zoneinfo default timezone implementation ¶ Our Free Tool Is Better Than Most Expense Tracker Templates You could also create a personal monthly budget planner by using this sheet. When you track your spending and expenses, you'll be able to see how much your spending fluctuates monthly as well as see where you need to store extra money.īased on last month's expense tracker, you may find you'll need to increase your savings for this month. The IRS requires that every business report any income, even if you do not receive a 1099 form for less than $600.Īs an owner or sole proprietor, any non-W2 income must be documented and reported on your tax returns as well. This section would come in handy when you actually do file your taxes as well. You could also download our free self-employment ledger template to track income and expenses.īy keeping a log of your earned income throughout the year, you can stay on top of the financial budgeting for your business and it's financial wellness. Our spreadsheet has a tab to track your company's income which is especially useful to be used as a budget tracker as well. The IRS uses a system to see the average spending for expenses for everyone in a particular field of work, and if your deductions are too far from the averages, it could trigger an IRS audit.īudgeting is important for any company. If the current year, your tracking shows that you wrote off 35%, it could be a red flag. Let's say in the previous year's Schedule C, you wrote off 15% of your income for meals. the expense types has too much variance or the numbers don't add up, you may need to make adjustments. It is important that you copy and paste your previous year's Schedule C as well to compare it with the current year or new Schedule C. Most of the time, this section of the excel template will be the easiest to use and adjust for your specific company. You may find you need to add other categories if you receive more than the typical expense types listed on our sheet. Our spreadsheet has the most common categories for your Schedule C Expense Categories. Enter the date you received the funds, the merchant who paid you, the expense amount, and the Schedule C category. The Schedule C tab on the sheet is pretty straightforward. The study suggested that there is a link between smaller jaws and regularly chewing very high-quality soft food. The stresses of chewing made the upper and lower jaws of the pigs eating hard food grow larger. In one experiment, he fed soft food to one group of pigs, hard food to another. As bones grow, their size and shape respond to biomechanical stresses, so he decided to study the effects of chewing hard versus soft food on the growth and development of the skull in various animal species. About nine years ago, while contemplating why human faces have become smaller in the brief span of recorded history-too short a time for evolution to explain-Lieberman wondered whether the modern diet of soft food might be a contributing factor. (The book draws on the expertise of many scholars as well as his own work.) Experimental biomechanics is one. To probe such mysteries, Lieberman uses a variety of techniques. In short: Why does the head look the way it does? Nevertheless, Lieberman takes up all sorts of interesting questions, such as why humans have big noses (there is a link to running), chins (nobody really knows), small faces that are tucked under the brain, and teeth that are suitable only for eating processed food. Though written so anyone can read it, The Evolution of the Human Head (Harvard University Press) “is not meant to be a bestseller,” he avers. Not only do heads contain many modules (instructions for building an eye to see, for example, or an ear to listen), but each module is itself “intensely integrated in terms of development, structure, and function….Changes to the size, the shape, or the relative timing of development of each of the head’s many modules offer a variety of opportunities for change.” Studying the head’s modules, Lieberman writes, may help us understand why “the human head has changed substantially since our lineage diverged from the chimpanzee’s lineage.” It also provides an opportunity for “exploring how nature tinkers with development in ways that affect function and permit the evolution of complex structures.” “How is it,” he asks, “that something so complicated and so vital can also be so evolvable?” One explanation involves modularity and integration. For example, the roof of the orbits is the floor of the brain-if one changes, they both do. On the other hand, it is where natural selection can and has acted powerfully to make us what we are.” Everything is closely connected. “The head presents an interesting evolutionary paradox,” explains Lieberman, chair of the new department of human evolutionary biology, “because on the one hand it is so complicated that if anything goes wrong, the organism dies. Lieberman’s book considers in detail how each of these functions works from a biomechanical perspective, and then theorizes how each evolved, simultaneously with the others, as part of an integrated whole. “It is the size of a soccer ball, and think what it does”: seeing, hearing, tasting, smelling, balancing, thinking, speaking, chewing, swallowing, breathing, and regulating body temperature. “Many of the things we value most-our big brains, speech, much of our sensory biology-are in the head,” Lieberman explains. The theory that humans evolved to become endurance runners so talented that a team of barefoot hunters on a hot African savanna could actually run a large antelope to ground is based in part on skeletal evidence from the head-a subject about which Lieberman has just published a weighty book, 15 years in the making. It’s bizarre.”īut the apparent dichotomy is bizarre only in the abstract, because Lieberman’s interest in feet-and human endurance running-began with his interest in heads. “I never thought that would happen in my career. “I do seem to end up working on the two ends of the body, and not so much in between,” he muses. These collections neatly bracket the research interests of Daniel Lieberman, human evolutionary biologist: a head-to-toe interest in the human body, its morphology (the science of an organism’s form, including the study of specific structural features), its development, and its evolution. The shoes are likewise varied, from brightly colored Nikes, to fluorescent ASICS, to slipper-like Vibram FiveFingers™ with separated toes-like a glove-intended to mimic barefoot running. The skulls come in a range of sizes and shapes, from the tiny and sharp-toothed, with large orbits for the eyes, to the hefty and humanoid. Beneath shelves of books on the biology of bone, a collection of skulls and running shoes lies in a jumble on a countertop. |
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